Prof. Chueh Loo Poh

Associate Professor, Biomedical Engineering

National University of Singapore

poh.chuehloo@nus.edu.sg

Professor Poh obtained a PhD in Bioengineering from Imperial College London, UK and a Bachelor of Engineering (Electrical & Electronic) with Honours (First Class) from Nanyang Technological University (NTU), Singapore. Professor Poh is interested in the development of new tools for synthetic biology and in the use of a model-based approach for biodesign.

Research Interests

My Engineering Biology research group @ NUS focuses on Synthetic Biology to address challenges in different areas including healthcare and environment. We apply engineering principles to design and build microbes with useful capabilities for medical and industrial applications and developing foundational platform tools to accelerate the design and engineering of the microbes. This includes synthetic gene circuits design and automation, modelling of biological systems, and computer aided design tools for SynBio. We have been “reprogramming” microbes to tackle metabolic diseases, to fight infectious causing pathogen and to control biofilm formation. Our motivation is to make engineering of biology more efficient and predictive so that we can scale complexity in order to create novel solutions to tackle global challenges.

Publications

Selected Publications

Jayaraman P, Devarajan K, Chua TK, Zhang H, Gunawan E, Poh CL. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res. (2016) Jun 28.
Peck, Y., He, P., Chilla, G.S.V.N., Poh, C.L., Wang, D.-A. A preclinical evaluation of an autologous living hyaline-like cartilaginous graft for articular cartilage repair: A pilot study (2015)
Yang, Y., Wu, Y., Hu, Y., Cao, Y., Poh, C.L., Cao, B., Song, H. Engineering Electrode-Attached Microbial Consortia for High-Performance Xylose-Fed Microbial Fuel Cell (2015), 5 (11), pp. 6937-6945.
Ling HT Maurice^, and CL Poh. A predictor for predicting Escherichia coli transcriptome and the effects of gene perturbations. 15:140, 2014.
Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, and Chang MW Reprogramming microbes to be a pathogen-seeking killer. 2014.
N. Saeidi, M Arshath*, MW Chang, CL Poh. Characterization of a quorum sensing device for synthetic biology design: Experimental and modeling validation. 103, 91-99. 2013
N Saeidi, CK Wong, T Lo, HX Nguyen, H Ling, SSJ Leong, CL Poh, and MW Chang. Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. 7:521, 2011.
B. Sana, E. Johnson, K Sheah, CL Poh, S Lim. Iron-based ferritin nanocore as a contrast agent. vol. 5, no. 3, FA48-52, 2010.