Dr. Ee Lui Ang
Department Head, Strain Engineering
A*STAR Singapore Institute of Food and Biotechnology Innovation(A*STAR SIFBI)
ang_ee_lui@sifbi.a-star.edu.sg
Ee Lui Ang received his joint PhD degree in Chemical and Biomolecular Engineering from the University of Illinois at Urbana-Champaign and the National University of Singapore in 2007. He then joined Codexis Laboratories Singapore, where he held the positions of Project Technical Lead, Molecular and Cellular Biology Team Leader, and Project Manager for a bioindustrial project. Ang joined A*STAR’s then-Institute of Chemical and Engineering Sciences (ICES) in 2012 as a Team Leader of the Metabolic Engineering Research Lab, and subsequently A*STAR’s Singapore Institute of Food and Biotechnology Innovation (SIFBI) in 2020 as a Team Leader in the Discovery and Transformation division. He currently leads SIFBI’s Strain Engineering Group. His research interests are in developing metabolic engineering and synthetic biology tools and strategies to engineer proteins, pathways and genomes for advanced biomanufacturing.
Research Areas
Synthetic Biolong Metabolic Engineering Enzyme Engineering Precision Fermentation
Publications
Selected Journals
- J. Liang, H. Zhang, Y.L. Tan, H. Zhao, and E.L. Ang, Directed Evolution of Replication-Competent Double-Stranded DNA Bacteriophage toward New Host Specificity, 2022, ACS Synthetic Biology, 11 (2), p634-643
- Y. Zhou, X. Xu, Y. Wei, Y. Cheng, Y. Guo, I. Khudyakov, F. Liu, P. He, Z. Song, Z.Li, Y. Gao, E.L. Ang, H. Zhao, Y. Zhang and S. Zhao, A widespread pathway for substitution of adenine by diaminopurine in phage genomes, 2021, Science, 372 (6541), p512-516
- H. Sun, H. Zhao, and E.L. Ang, A New Biosensor for Stilbenes and a Cannabinoid Enabled by Genome Mining of a Transcriptional Regulator, 2020, ACS Synthetic Biology, DOI: 10.1021/acssynbio.9b00443
- M. M. Zhang, F. Wong, Y. Wang, S. Luo, Y. H. Lim, E. Heng, W. L. Yeo, R. E Cobb, B. Enghiad, E.L. Ang, and H. Zhao, An Efficient CRISPR-Cas9 Mediated Knockin Strategy for Activation of Silent Streptomyces Biosynthetic Gene Clusters for Natural Product Discovery, Nature Chemical Biology, 2017, 13, p607–609
- H. Sun, W.L. Yeo, Y.H. Lim, X. Chew, D.J. Smith, B. Xue, K.P. Chan, R.C. Robinson, E.G. Robins, H. Zhao, and E.L. Ang, Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non‐native Substrate, 2016, Angewandte Chemie International Edition, 55 (46), p14277-14280
- An Improved Galactose Oxidase Enzyme Panel For Oxidation Of Secondary Alcohols, Singapore Patent Application No. 10202250709V, 2022
- Enzymes and Uses in Biocatalytic Halogenation of N-Heteroaryls Thereof, Singaporean Provisional Patent Application No. 10202205361W, 2022
- Biocatalysis and Methods for the Synthesis of Armodafinil, US Patent 20210198638, 2021
- Polynucleotides encoding cyclohexanone monooxygenases, US10557126B2, 2020
